A novel, simple, accurate, sensitive and reproducible spectroscopic method was developed and validated for the estimation of Rosuvastatin Calcium and Clopidogrel Bisulphate in combined dosage form. The method obeys Beer’s Law in concentration ranges of 4-12 µg/ml for Rosuvastatin Calcium and 30-90 µg/ml Clopidogrel Bisulphate both. The method was validated for linearity, accuracy and precision as per ICH guidelines. The zero crossing point for Rosuvastatin Calcium and Clopidogrel Bisulphate was 242.20 nm and 265.60 nm respectively in methanol. The LOD and LOQ value were found to be 1.86 µg/ml and 5.65 µg/ml for Rosuvastatin Calcium, 4.20 µg/ml and 12.72 µg/ml for Clopidogrel Bisulphate respectively. The accuracy of the method was assessed by recovery studies was found to be 100.23 ± 0.3055 and 99.78 ± 0.3426 for Rosuvastatin Calcium and Clopidogrel Bisulphate respectively. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage forms.
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